Immune Response Versus Susceptibility to Marek’s Disease

Chondrocyte antigen expression, immune response and susceptibility to arthritis.

The association of HLA-B27 with certain forms of arthritis implies a role for MHC class I-restricted T cells in the arthritic process. Our aim was to study CD8(+) T cell responses towards specific antigens localized in joint tissue. Known determinants were introduced into chondrocytes of transgenic (TG) mice, under the control of the cis-regulatory sequences of the human type II collagen gene (...

Genetic Control of Immune Response and Susceptibility to Infectious Diseases

1 Department of Biotechnology, Center for Biosciences and Biotechnology, State University of Norte Fluminense Darcy Ribeiro, 28013-602 Campos dos Goytacazes, RJ, Brazil 2 Emory Vaccine Center, Yerkes National, Primate Research Center, Emory University, Atlanta, GA 30329, USA 3 Laboratory of Immunogenetics, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, 0550...

Stress, immune reactivity and susceptibility to infectious disease.

Psychological stress is known to affect immune function and to predict infectious disease susceptibility. However, not all individuals who are stressed develop disease. In the present article, we report on a series of studies from our laboratory describing interindividual variability of immune responses to psychological stress. In our initial series of experimental investigations, we demonstrat...

The human immune response to Toxoplasma: Autophagy versus cell death

Introduction Toxoplasma gondii is an obligate intracellular parasite that can infect a broad range of warmblooded animals. In humans, it can cause serious disease in immune-compromised individuals or if contracted congenitally. In North America and Europe, strains belonging to the clonal types I, II, and III haplogroups predominate, while in South America a large variety of other “atypical” str...

Evaluation of Acute Aflatoxicosis on Humoral Immune Response to Foot-and Mouth Disease Vaccination in Guinea Pigs